Updated Recommendation
A new evidence synthesis was published:2022, WHO guidelines for malaria, 3 June 2022.
View latest version (2022)Bibliographic Info
Recommendation
Recommended in favor
Conditional
Certainty of evidence
Moderate
Pyrethroid-PBO nets prequalified by WHO are conditionally recommended for deployment instead of pyrethroidonly insecticide-treated nets (ITNs) where the principal malaria vector(s) exhibit pyrethroid resistance that is: a)confirmed, b) of intermediate level, and c) conferred (at least in part) by a monooxygenase-based resistance mechanism, as determined by standard procedures.
Notes and Remarks
- 1.WHO recommends pyrethroid-PBO nets that have been prequalified by WHO for areas where resistance in the principal malaria vector(s) is: a) confirmed, b) of intermediate level and c) conferred (at least in part) by a monooxygenasebased resistance mechanism, as determined by standard procedures.
- 2.Pyrethroid-PBO nets combine pyrethroids and a synergist, which acts by inhibiting certain metabolic enzymes within the mosquito before they can have a toxic effect . Therefore, compared to a pyrethroid-only net, a pyrethroid-PBO net should have an increased killing effect on malaria vectors that express such resistance mechanisms.
Also Featured In
This recommendation also appears in the following guidelines:
Guidelines for Malaria Vector Control
WHO guidelines for malaria, 16 February 2021.
WHO guidelines for malaria, 13 July 2021.
WHO Guidelines for malaria, 14 March 2023