Bibliographic Info
GuidelineWHO guidelines for malaria, 16 October 2023.
Year of Publication2023
Issuing InstitutionWorld Health Organization
Recommendation
Status
Updated
Recommended in favor
Conditional
Certainty of evidence
Moderate
Pyrethroid-PBO ITNs instead of pyrethroid-only LLINs can be deployed for the prevention and control of malaria in children and adults in areas with ongoing malaria transmission where the principal malaria vector(s) exhibit pyrethroid resistance.
Notes and Remarks
- 1.WHO recommends pyrethroid-PBO nets that have been prequalified by WHO for areas where resistance in the principal malaria vector(s) is: a) confirmed, b) of intermediate level and c) conferred (at least in part) by a monooxygenasebased resistance mechanism, as determined by standard procedures.
- 2.Pyrethroid-PBO nets combine pyrethroids and a synergist, which acts by inhibiting certain metabolic enzymes within the mosquito before they can have a toxic effect . Therefore, compared to a pyrethroid-only net, a pyrethroid-PBO net should have an increased killing effect on malaria vectors that express such resistance mechanisms.