Updated Recommendation
A new evidence synthesis was published:2024, WHO consolidated guidelines on tuberculosis: module 1: prevention: tuberculosis preventive treatment, 2nd ed
View latest version (2024)Bibliographic Info
Recommendation
Recommended in favor
Conditional
Certainty of evidence
Low
In settings with high TB transmission, adults and adolescents living with HIV who have an unknown or a positive latent TB infection test and are unlikely to have active TB disease should receive at least 36 months of daily isoniazid preventive therapy. Daily isoniazid preventive therapy for 36 months should be given whether or not the person is receiving ART and irrespective of the degree of immunosuppression, history of previous TB treatment and pregnancy in settings considered to have high TB transmission as defined by national authorities
Also Featured In
This recommendation also appears in the following guidelines:
WHO policy on collaborative TB/HIV activities : guidelines for national programmes and other stakeholders
Guidelines for intensified tuberculosis case-finding and isoniazid preventive therapy for people living with HIV in resource-constrained settings
Recommendation on 36 months isoniazid preventive therapy to adults and adolescents living with HIV in resource-constrained and high TB- and HIV-prevalence settings – 2015 update
Consolidated guidelines on the use of antiretroviral drugs for treating and preventing HIV infection: recommendations for a public health approach
Latent tuberculosis infection: updated and consolidated guidelines for programmatic management
Consolidated guidelines on HIV prevention, testing, treatment, service delivery and monitoring: recommendations for a public health approach
WHO consolidated guidelines on tuberculosis: module 5: management of tuberculosis in children and adolescents.
WHO consolidated guidelines on tuberculosis: module 6: tuberculosis and comorbidities.
WHO consolidated guidelines on tuberculosis: module 6: tuberculosis and comorbidities, 2nd ed.