WHO TO TREAT AND WHO NOT TO TREAT IN PERSONS WITH CHRONIC HEPATITIS B. Antiviral therapy is not recommended and can be deferred in persons without clinical evidence of cirrhosis (or based on APRI score ≤2 in adults), and with persistently normal ALT levels and low levels of HBV DNA replication (HBV DNA <2000 IU/mL), regardless of HBeAg status or age