Bibliographic Info
GuidelineWHO recommendations on antenatal care for a positive pregnancy experience
Year of Publication2016
Issuing InstitutionWHO
Recommendation
Status
Updated
Recommendation in research context
Only in research contexts
Certainty of evidence
Very low
Antenatal prophylaxis with anti-D immunoglobulin in non-sensitized Rh-negative pregnant women at 28 and 34 weeks of gestation to prevent RhD alloimmunization is recommended only in the context of rigorous research. (Context-specific recommendation – research)
Notes and Remarks
- 1.This context-specific recommendation relates to anti-D prophylaxis during pregnancy and not the practice of giving anti-D after childbirth, for which there is high-certainty evidence of its effect of reducing RhD alloimmunization in subsequent pregnancies. Anti-D should still be given postnatally when indicated.
- 2.Determining the prevalence of RhD alloimmunization and associated poor outcomes among women in LMIC settings, as well as developing strategies to manage this condition, is considered a research priority