Monotherapy with lamotrigine or levetiracetam should be offered as first-line treatment for focal onset seizures in children and adults with epilepsy. If neither lamotrigine nor levetiracetam are available, then carbamazepine should be used as an alternate first-line treatment for focal onset seizures in children and adults with epilepsy. If the first monotherapy is not successful for focal onset seizures, an alternative first-line monotherapy should be tried. Lacosamide should be offered as a second-line monotherapy for focal onset seizures if none of the first-line medicines are effective. If antiseizure medicine monotherapy is unsuccessful in people with generalized onset seizures or focal onset seizures, prompt referral should be made to a specialist for consideration of other treatment options.