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Bibliographic Info

GuidelineGuidelines for the diagnosis, prevention, and management of cryptococcal disease in HIV-infected adults, adolescents and children, March 2018: supplement to the 2016 consolidated guidelines of the use of antiretroviral drugs for treating and preventing HIV infection
Year of Publication2018
Issuing InstitutionWorld Health Organization

Recommendation

Status
Maintained

Recommended in favor

Strong

Fluconazole (800 mg daily for adults, 6–12 mg/kg/day for children and adolescents up to a maximum of 800 mg daily) is recommended for the consolidation phase (for eight weeks following the induction phase)

Notes and Remarks

A minimum package of pre-emptive hydration and electrolyte replacement and toxicity monitoring and management should be provided to minimize treatment toxicity during induction phase with amphotericin B containing regimens and flucytosine.

Also Featured In

This recommendation also appears in the following guidelines:

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Consolidated guidelines on HIV prevention, testing, treatment, service delivery and monitoring: recommendations for a public health approach

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Guideline

Guidelines for diagnosing, preventing and managing cryptococcal disease among adults, adolescents and children living with HIV.

Year2022
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WHO guidelines on the management of advanced HIV disease

Year2025
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