Bibliographic Info
Recommendation
Recommended in favor
Strong
Certainty of evidence
Moderate
The following induction regimens are recommended as alternative options depending on drug availability: Two weeks of amphotericin B deoxycholate (1.0 mg/kg/day) + fluconazole (1200 mg daily for adults, 12 mg/kg/day for children and adolescents up to a maximum of 800 mg daily
Notes and Remarks
A minimum package of pre-emptive hydration and electrolyte replacement and toxicity monitoring and management should be provided to minimize treatment toxicity during induction phase with amphotericin B containing regimens and flucytosine.
Also Featured In
This recommendation also appears in the following guidelines:
Guidelines for the diagnosis, prevention, and management of cryptococcal disease in HIV-infected adults, adolescents and children, March 2018: supplement to the 2016 consolidated guidelines of the use of antiretroviral drugs for treating and preventing HIV infection