Bibliographic information
GuidelineConsolidated HIV guidelines: service delivery
Year of Publication2026
Issuing InstitutionWorld Health Organization
Recommendation
New
Rapid Antiretroviral therapy (ART) initiation should be offered to all people with HIV following a confirmed HIV diagnosis and clinical assessment
Recommended in favor
Strong
Certainty of evidence
High
Notes and Remarks
Rapid initiation is defined as within seven days from the day of HIV diagnosis; people with advanced HIV disease should be given priority for assessment and initiation.
- Treatment literacy and psychosocial readiness for initiation should be assessed. However, initiation should not be delayed to complete counselling content. Counselling should be scheduled over the initial weeks of treatment. Consider options to provide this initial counselling and assessment of treatment literacy remotely or in the community.
- Confirmatory HIV testing should be carried out. CD4 cell count testing and clinical assessment should be performed to determine whether the client has advanced HIV disease and to prevent opportunistic infections.
- Among people with TB symptoms, evidence supports starting ART while investigating for TB (10). ART initiation should be delayed among people with meningitis and cryptococcal meningitis because of the increased risk of severe adverse events and immune reconstitution inflammatory syndrome. Cryptococcal meningitis is diagnosed with serum cryptococcal antigen screening and confirmed by cerebrospinal fluid analysis.
- People should not be coerced to start immediately and should be supported in making an informed choice regarding when to initiate ART.