Guideline

Lateral flow urine lipoarabinomannan assay (LF-LAM) for the diagnosis of active tuberculosis in people living with HIV: policy update 2019

Year of Publication

2019

Issuing Institution

World Health Organization

Links

WHO IRIS,WHO IRIS

Recommendations

8 included recommendations

In inpatient settings, WHO strongly recommends using lateral flow urine lipoarabinomannan assay (LF-LAM) to assist in the diagnosis of active TB in HIV-positive adults, adolescents and children: with signs and symptoms of TB (pulmonary and/or extrapulmonary

Status

Maintained

Recommended in favor

Strong

Certainty of evidence

Moderate

In inpatient settings, WHO strongly recommends using lateral flow urine lipoarabinomannan assay (LF-LAM) to assist in the diagnosis of active TB in HIV-positive adults, adolescents and children: with advanced HIV disease or who are seriously ill

Status

Retired

Recommended in favor

Strong

Certainty of evidence

Moderate

In inpatient settings, WHO strongly recommends using lateral flow urine lipoarabinomannan assay (LF-LAM) to assist in the diagnosis of active TB in HIV-positive adults, adolescents and children: irrespective of signs and symptoms of TB and with a CD4 cell count < 200

Status

Maintained

Recommended in favor

Strong

Certainty of evidence

Moderate

In outpatient settings, WHO suggests using lateral flow urine lipoarabinomannan assay (LF-LAM) to assist in the diagnosis of active TB in HIV-positive adults, adolescents and children: with signs and symptoms of TB (pulmonary and/or extrapulmonary) or seriously ill

Status

Maintained

Recommended in favor

Conditional

Certainty of evidence

Low

In outpatient settings, WHO suggests using lateral flow urine lipoarabinomannan assay (LF-LAM) to assist in the diagnosis of active TB in HIV-positive adults, adolescents and children: irrespective of signs and symptoms of TB and with a CD4 cell count < 100

Status

Maintained

Recommended in favor

Conditional

Certainty of evidence

Very low

In outpatient settings, WHO recommends against using lateral flow urine lipoarabinomannan assay (LF-LAM) to assist in the diagnosis of active TB in HIV-positive adults, adolescents and children: without assessing TB symptoms

Status

Retired

Recommended against

Strong

Certainty of evidence

Very low

In outpatient settings, WHO recommends against using lateral flow urine lipoarabinomannan assay (LF-LAM) to assist in the diagnosis of active TB in HIV-positive adults, adolescents and children: without TB symptoms and unknown CD4 cell count, or without TB symptoms and CD4 cell count ≥ 200

Status

Maintained

Recommended against

Strong

Certainty of evidence

Very low

In outpatient settings, WHO recommends against using lateral flow urine lipoarabinomannan assay (LF-LAM) to assist in the diagnosis of active TB in HIV-positive adults, adolescents and children: without TB symptoms and witha CD4 cell count of 100–200

Status

Maintained

Recommended against

Conditional

Certainty of evidence

Very low